Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model

@article{Hahn2011EnhancedCE,
  title={Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model},
  author={Woong Hahn and Wook Bum Pyun and Dong Sik Kim and Wonsun Yoo and Sung-Dong Lee and Jung-Hee Won and Gil Ja Shin and Jong‐Mook Kim and Sunyoung Kim},
  journal={The Journal of Gene Medicine},
  year={2011},
  volume={13}
}
The therapeutic potential of pCK‐HGF‐X7, a naked DNA designed to express two isoforms of hepatocyte growth factor (HGF723 and HGF728), was studied in the rat ischemic heart disease model. 
A phase I clinical study of naked DNA expressing two isoforms of hepatocyte growth factor to treat patients with critical limb ischemia
The purpose of the present phase I clinical trial was to evaluate the safety, tolerability, and preliminary efficacy of naked DNA therapy expressing two isoforms of hepatocyte growth factorExpand
Angiogenesis-Based Strategy by Hepatocyte Growth Factor for the Treatment of Ischemic Organ Diseases: From Biology to Clinical Trials
TLDR
A therapeutic potential of HGF will be discussed, with a focus on biological mechanisms and preclinical or clinical outcomes during ischemic organ diseases. Expand
Effects of Recombinant Adenovirus Hepatocyte Growth Factor Gene on Myocardial Remodeling in Spontaneously Hypertensive Rats
TLDR
Findings indicate that HGF expression is attenuated in hypertrophic and fibrotic myocardium of SHR and the forced increase in HGF exerts a salutary effect on myocardial fibrosis, collagen I expression, and hemodynamic parameters. Expand
Double-blind, placebo-controlled study of HGF gene therapy in diabetic neuropathy
To evaluate the safety and efficacy of a plasmid (VM202) containing two human hepatocyte growth factor isoforms given by intramuscular injections in patients with painful diabetic neuropathy.
Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia
TLDR
The data suggest that VM202 is safe and may provide therapeutic bioactivity in CLI patients and significant differences were seen in TcPO2 between the high-dose and placebo groups at 12 months. Expand
Hepatocyte Growth Factor Regulates Macrophage Transition to the M2 Phenotype and Promotes Murine Skeletal Muscle Regeneration
TLDR
The findings suggested that HGF/c-met might play an important role in the transition of the macrophage during muscle repair, indicating the potential use of HGF as a basis for developing therapeutics for muscle degenerative diseases. Expand
Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model
TLDR
Data show that pCK‐HGF‐X7 attenuates nerve injury‐induced neuropathic pain by inhibiting pain‐related factors in DRG neurons and subsequent spinal cord glial activation, which suggests its therapeutic efficacy in the treatment of neuropathicPain. Expand
Hepatocyte Growth Factor Regulates the miR-206-HDAC4 Cascade to Control Neurogenic Muscle Atrophy following Surgical Denervation in Mice
TLDR
HGF expression was found to be upregulated in skeletal muscle tissue following surgical denervation and in hSOD1-G93A transgenic mice showing severe muscle loss, suggesting that HGF might play an important role in regard to neurogenic muscle atrophy and that H GF might be used as a platform to develop therapeutic agents for neuromuscular disorders. Expand
Insights into gene therapy for critical limb ischemia: the devil is in the details.
TLDR
New studies examining each of these angiogenic factors provide insights that will be useful for the design of effective therapeutic strategies, with HGF gene therapy being the most successful. Expand
Intramyocardial transfer of hepatocyte growth factor as an adjunct to CABG: phase I clinical study
TLDR
Intramyocardial injection of VM202 can be safely used in IHD patients with the tolerable dose of 2.0 mg and VM202 might appear to have improved regional myocardial perfusion and wall thickness in the injected region. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 24 REFERENCES
A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats.
TLDR
The c-Met/HGF receptor is induced in cardiomyocytes following myocardial infarction and HGF exhibits protective effect on cardiomeocytes against oxidative stress. Expand
Naked DNA expressing two isoforms of hepatocyte growth factor induces collateral artery augmentation in a rabbit model of limb ischemia
TLDR
Results showed that transfer of the genomic–cDNA hybrid of the HGF gene could be used as a potential therapeutic approach to human vascular diseases. Expand
Therapeutic angiogenesis using naked DNA expressing two isoforms of the hepatocyte growth factor in a porcine acute myocardial infarction model.
TLDR
Intramyocardial injection of naked DNA expressing two isoforms of hepatocyte growth factor induced significant angiogenesis at infarct-border zone, and increased the left ventricular stroke volume probably caused by reverse remodeling process. Expand
Therapeutic angiogenesis using hepatocyte growth factor (HGF).
TLDR
A potential therapeutic strategy using HGF in cardiovascular disease is discussed, which has been demonstrated the potential application of HGF to treat cardiovascular diseases such as peripheral vascular disease, myocardial infarction and cerebrovascular disease. Expand
Gene Transfer of Hepatocyte Growth Factor Attenuates Postinfarction Heart Failure
TLDR
Hepatocyte Growth Factor gene transfer following a large myocardial infarction results in significantly preserved myocardIAL function and geometry, and is associated with significant angiogenesis and a reduction in apoptosis. Expand
Gene transfer of hepatocyte growth factor improves angiogenesis and function of chronic ischemic myocardium in canine heart.
TLDR
Gene transfection of HGF improved angiogenesis, thereby improved regional myocardial function and perfusion in chronic ischemic myocardium, indicating a potent therapeutic value of H GF gene transfections for chronic isChemic heart diseases such as myocardIAL infarction. Expand
Myocardial Regeneration Therapy for Heart Failure: Hepatocyte Growth Factor Enhances the Effect of Cellular Cardiomyoplasty
TLDR
Combined therapy may be a promising strategy for the treatment of heart failure caused by myocardial infarction by stimulating angiogenesis, restoring the impaired ECM, and promoting the integration of the dissociated grafted myocytes. Expand
Hepatocyte growth factor and its variant with a deletion of five amino acids are distinguishable in their biological activity and tertiary structure.
TLDR
Comparing HGF and the deletion variant (dHGF) revealed that the deletion significantly altered the biological activities, solubility, and immunological property of HGF, and the structural change in HGF may be responsible for its altered biological activities andsolubility. Expand
Safety Evaluation of Clinical Gene Therapy Using Hepatocyte Growth Factor to Treat Peripheral Arterial Disease
TLDR
The initial clinical outcome with HGF gene transfer seems to indicate usefulness as sole therapy for CLI and safe and feasible injection of naked HGF plasmid DNA is safe, feasible, and can achieve successful improvement of ischemic limbs. Expand
Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia
TLDR
HGF gene therapy is safe and effective for CLI and improved quality of life (QOL) and there were no major safety problems. Expand
...
1
2
3
...