Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.

@article{Tesio2011EnhancedCA,
  title={Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.},
  author={Melania Tesio and Karin Golan and Simona Corso and Silvia Giordano and Amir Schajnovitz and Yaron Vagima and Shoham Shivtiel and Alexander Kalinkovich and Luisa Caione and Loretta Gammaitoni and Elisa Laurenti and Eike C. Buss and Elias Shezen and Tomer Itkin and Orit Kollet and Isabelle Petit and Andreas Trumpp and James G. Christensen and Massimo Aglietta and Wanda Piacibello and Tsvee Lapidot},
  journal={Blood},
  year={2011},
  volume={117 2},
  pages={
          419-28
        }
}
Mechanisms governing stress-induced hematopoietic progenitor cell mobilization are not fully deciphered. We report that during granulocyte colony-stimulating factor-induced mobilization c-Met expression and signaling are up-regulated on immature bone marrow progenitors. Interestingly, stromal cell-derived factor 1/CXC chemokine receptor-4 signaling induced hepatocyte growth factor production and c-Met activation. We found that c-Met inhibition reduced mobilization of both immature progenitors… CONTINUE READING

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