Enhanced brain targeting efficacy of Olanzapine through solid lipid nanoparticles.

  title={Enhanced brain targeting efficacy of Olanzapine through solid lipid nanoparticles.},
  author={Jawahar Natarajan and Mahendran Baskaran and Lireni C Humtsoe and Ramachandran Vadivelan and Antony Justin},
  journal={Artificial cells, nanomedicine, and biotechnology},
  volume={45 2},
Olanzapine (OLZ) is a typical anti-psychotic drug, which is highly lipophilic in nature, belongs to Biopharmaceutical Classification System (BCS) class II category. Though OLZ is an effective agent in the treatment of Schizophrenia, but it exhibits poor bioavailability (57%) due to extensive first-pass metabolism resulted in high dose is required to achieve therapeutic concentration in brain. Emerging evidences are indicating that high dose administration of OLZ may cause Extrapyramidal… CONTINUE READING
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