Enhanced biological activity of polymeric osteopontin.

  title={Enhanced biological activity of polymeric osteopontin.},
  author={Fumiko Higashikawa and Akira Eboshida and Yasuyuki Yokosaki},
  journal={FEBS letters},
  volume={581 14},
Osteopontin is a multifunctional glycoprotein with roles in immunomodulation, inflammatory response, tissue mineralization, and tissue remodeling, which are mediated primarily through integrins. Transglutaminase 2 selectively cross-links proteins by isopeptide bonding. Osteopontin is one of the substrates of this enzyme and undergoes polymerization; however, the biological meaning of this polymerization remains unknown. Using recombinant osteopontin polymerized with purified transglutaminase 2… CONTINUE READING
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Image Processing with ImageJ Biophotonics International 11,36-42

M. Abramoff, P. Magelhaes, S. Ram

Tissue transglutaminase and its substrates in bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2002