Enhanced biological activity of polymeric osteopontin.

@article{Higashikawa2007EnhancedBA,
  title={Enhanced biological activity of polymeric osteopontin.},
  author={Fumiko Higashikawa and Akira Eboshida and Yasuyuki Yokosaki},
  journal={FEBS letters},
  year={2007},
  volume={581 14},
  pages={
          2697-701
        }
}
Osteopontin is a multifunctional glycoprotein with roles in immunomodulation, inflammatory response, tissue mineralization, and tissue remodeling, which are mediated primarily through integrins. Transglutaminase 2 selectively cross-links proteins by isopeptide bonding. Osteopontin is one of the substrates of this enzyme and undergoes polymerization; however, the biological meaning of this polymerization remains unknown. Using recombinant osteopontin polymerized with purified transglutaminase 2… CONTINUE READING
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