Enhanced bioavailability of total paeony glycoside by self-microemulsifying drug delivery system.

@article{Chen2012EnhancedBO,
  title={Enhanced bioavailability of total paeony glycoside by self-microemulsifying drug delivery system.},
  author={Li-Jiang Chen and Yang Liu and Carilyn Torruellas and Fei Gao},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={2012},
  volume={47 12},
  pages={1678-86}
}
Total paeony glycoside (TPG) is extracted and purified from a traditional Chinese herbal medicine. It has many biological and pharmacological activities. However, there are few dosage forms of TPG in the market because of its low bioavailability. Self-microemulsifying drug delivery system (SMEDDS) is a vital tool in solving low bioavailability of poor absorption drugs. So the objective of this study is to develop a new TPG-SMEDDS for the oral delivery of poorly soluble TPG. Through the… CONTINUE READING