Enhanced bioavailability of piroxicam via salt formation with ethanolamines.

  title={Enhanced bioavailability of piroxicam via salt formation with ethanolamines.},
  author={H S Gwak and Jun-shik Choi and Hoo-Kyun Choi},
  journal={International journal of pharmaceutics},
  volume={297 1-2},
Piroxicam can be ionized as a zwitterion that has two pKa values (pKa1=1.86 and pKa2=5.46). Consequently, piroxicam has a low solubility in both polar and nonpolar media, and a low lipophilicity, which results in a low permeability. Three piroxicam-ethanolamine salts were prepared, which had a higher area under the curve (AUC) than piroxicam. There were minimal differences in the AUC among the salt forms. It was reported that the piroxicam triethanolamine salt had a lower permeability across… CONTINUE READING

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