Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH

@article{Jensen1991EnhancedBO,
  title={Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH},
  author={Peter Egede Jensen},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={1111 - 1120}
}
Helper T lymphocytes recognize peptide antigens stably associated with class II major histocompatibility complex (MHC) glycoproteins on the surface of antigen-presenting cells and serve to regulate a wide variety of immune responses. A previous study from our laboratory had demonstrated that the functional association of various peptide antigens with the antigen-presenting cell membrane was increased at pH 5 as compared to pH 7, consistent with the potential role of acidic endosomal… CONTINUE READING