Enhanced binding of circulating SLE autoantibodies to catecholestrogen-copper-modified DNA

@article{Khan2008EnhancedBO,
  title={Enhanced binding of circulating SLE autoantibodies to catecholestrogen-copper-modified DNA},
  author={Wahid Ali Khan and Safia Ait Habib and Wajid Ali Mohd Khan and Khursheed Alam and Moinuddin},
  journal={Molecular and Cellular Biochemistry},
  year={2008},
  volume={315},
  pages={143-150}
}
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by circulating and tissue fixed autoantibodies reactive with self-antigens, including nucleic acid and other nuclear components. The pathways by which these autoantibodies act as a pathogenic factor remain elusive. Present study has investigated the role of estrogens in SLE etiopathogenesis. Estrogen-modified DNA [4-OHE2-Cu(II)-DNA] showed single- and double-strand breaks, hyperchromicity, decrease in Tm, and… CONTINUE READING
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