Enhanced binding and killing of target tumor cells by drug-loaded liposomes modified with tumor-specific phage fusion coat protein.

@article{Wang2010EnhancedBA,
  title={Enhanced binding and killing of target tumor cells by drug-loaded liposomes modified with tumor-specific phage fusion coat protein.},
  author={Tao Wang and Gerard G. M. D'Souza and Deepa Bedi and Olusegun A. Fagbohun and Lakshmi Prasanna Potturi and Brigitte Papahadjopoulos-Sternberg and Valery A. Petrenko and Vladimir Torchilin},
  journal={Nanomedicine},
  year={2010},
  volume={5 4},
  pages={
          563-74
        }
}
AIM To explore cancer cell-specific phage fusion pVIII coat protein, identified using phage display, for targeted delivery of drug-loaded liposomes to MCF-7 breast cancer cells. MATERIAL & METHODS An 8-mer landscape library f8/8 and a biopanning protocol against MCF-7 cells were used to select a landscape phage protein bearing MCF-7-specific peptide. Size and morphology of doxorubicin-loaded liposomes modified with the tumor-specific phage fusion coat protein (phage-Doxil) were determined by… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Filamentous phage biology

  • R Webster
  • 2007

Similar Papers

Loading similar papers…