Enhanced autophagy ameliorates cardiac proteinopathy.

@article{Bhuiyan2013EnhancedAA,
  title={Enhanced autophagy ameliorates cardiac proteinopathy.},
  author={Md Shenuarin Bhuiyan and J Scott Pattison and Hanna E Osinska and Jeanne C. James and James M. Gulick and Patrick Michael McLendon and Joseph A Hill and Junichi Sadoshima and Jeffrey Robbins},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 12},
  pages={
          5284-97
        }
}
Basal autophagy is a crucial mechanism in cellular homeostasis, underlying both normal cellular recycling and the clearance of damaged or misfolded proteins, organelles and aggregates. We showed here that enhanced levels of autophagy induced by either autophagic gene overexpression or voluntary exercise ameliorated desmin-related cardiomyopathy (DRC). To increase levels of basal autophagy, we generated an inducible Tg mouse expressing autophagy-related 7 (Atg7), a critical and rate-limiting… CONTINUE READING

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