Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.

@article{SezLlorens1991EnhancedAO,
  title={Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.},
  author={Xavier S{\'a}ez-Llorens and Hamid Jafari and C. Severien and F Alberca de Las Parras and Kurt D. Olsen and Eric J. Hansen and Irwin I. Singer and George H Mccracken},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={88 6},
  pages={2003-11}
}
Antiinflammatory therapy has been shown to reduce the adverse pathophysiological consequences that occur in bacterial meningitis and to improve outcome from disease. In the present study, modulation of two principal steps of the meningeal inflammatory cascade was accomplished by concomitant administration of dexamethasone to diminish overproduction of cytokines in response to a bacterial stimulus and of a monoclonal antibody directed against adhesion-promoting receptors on leukocytes to inhibit… CONTINUE READING