Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.

@article{Moser1997EnhancedAC,
  title={Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.},
  author={Markus Moser and Armin Pscherer and Claude Roth and J. Becker and Gabi Muecher and Klaus Zerres and Christa Dixkens and Joachim Weis and L. M. Guay-Woodford and Ralf Buettner and Reinhard F{\"a}ssler},
  journal={Genes & development},
  year={1997},
  volume={11 15},
  pages={1938-48}
}
Expression of AP-2 transcription factors has been detected previously in embryonic renal tissues. We show here that AP-2beta -/- mice complete embryonic development and die at postnatal days 1 and 2 because of polycystic kidney disease. Analyses of kidney development revealed that induction of epithelial conversion, mesenchyme condensation, and further glomerular and tubular differentiation occur normally in AP-2beta-deficient mice. At the end of embryonic development expression of bcl-X(L… CONTINUE READING