Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.

@article{Ogden2005EnhancedAC,
  title={Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.},
  author={Carol Anne Ogden and John D. Pound and Balvinder K. Batth and Sarah M. Owens and Ing{\'o}lfur Johannessen and Katrina Wood and Christopher D Gregory},
  journal={Journal of immunology},
  year={2005},
  volume={174 5},
  pages={3015-23}
}
Burkitt's lymphoma (BL) is typified by frequent tumor cell apoptosis and significant macrophage infiltration. Since BL cells have an inherent tendency to undergo apoptosis at a high rate, we reasoned that macrophages in BL are functionally enhanced in at least two activities that have implications for tumor pathogenesis: 1) engulfment of apoptotic cells, an anti-inflammatory process known to suppress immune responses, and 2) production of BL cell survival factors that limit the extent of tumor… CONTINUE READING

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