Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks.

@article{Korba2000EnhancedAB,
  title={Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks.},
  author={Brent E. Korba and Paul J. Cote and William E. Hornbuckle and Raymond F Schinazi and John L. Gerin and Bud Christopher Tennant},
  journal={Antiviral research},
  year={2000},
  volume={45 1},
  pages={19-32}
}
Cell culture studies in our laboratory and others have previously demonstrated synergistic antiviral activity for combinations of 3TC (lamivudine) and penciclovir against Hepatitis B Virus (HBV) replication and the Duck Hepatitis B Virus (DHBV). Based on these results, a study was designed to determine if an enhanced antiviral effect with combinations of 3TC and famciclovir (FCV, oral prodrug of penciclovir) could be demonstrated in vivo using the Woodchuck Hepatitis Virus (WHV)/woodchuck… CONTINUE READING

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