Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera.

@article{White2000EnhancedAA,
  title={Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera.},
  author={Mitchell R. White and Erika C. Crouch and D N Chang and Kedarnath N. Sastry and Neng-hua Guo and Georg Engelich and Kazue Takahashi and R . Alan B. Ezekowitz and Kevan L Hartshorn},
  journal={Journal of immunology},
  year={2000},
  volume={165 4},
  pages={2108-15}
}
The carbohydrate recognition domains (CRDs) of human serum mannose-binding lectin (MBL) and pulmonary surfactant protein D (SP-D) have distinctive monosaccharide-binding properties, and their N-terminal and collagen domains have very different quaternary structures. We produced a chimeric protein containing the N terminus and collagen domain of human SP-D and the neck region and CRD of human MBL (SP-D/MBLneck+CRD) to create a novel human collectin. The chimera bound to influenza A virus (IAV… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…