Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice

@inproceedings{Ye2017EnhancedAA,
  title={Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice},
  author={Lei Ye and Fangming Kan and Tao Yan and Jiaqi Cao and Leiliang Zhang and Zhijian Wu and Wuping Li},
  booktitle={Scientific Reports},
  year={2017}
}
The hepatitis B virus (HBV) causes acute and chronic liver infection, which may lead to liver cirrhosis and hepatocellular carcinoma. Current treatments including interferons and nucleotide analogs, have limited therapeutic effects, underscoring the need to identify effective therapeutic options to inhibit HBV replication and prevent complications. Previous animal models mimicking chronic HBV infection do not faithfully reflect disease progression in humans. Here, we used our established HBV… CONTINUE READING
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