Enhanced antitumor effects of the BRBP1 compound peptide BRBP1-TAT-KLA on human brain metastatic breast cancer

@inproceedings{Fu2015EnhancedAE,
  title={Enhanced antitumor effects of the BRBP1 compound peptide BRBP1-TAT-KLA on human brain metastatic breast cancer},
  author={Bo Fu and Wei Long and Ying Zhang and Aifeng Zhang and Fengqin Miao and Yuqing Shen and Ning Pan and Guangming Gan and Fang Nie and Youji He and Jianqiong Zhang and Gao-Jun Teng},
  booktitle={Scientific reports},
  year={2015}
}
Novel molecularly targeted agents that block the development and metastasis of human brain metastatic breast cancer hold great promise for their translational value. In this study, we constructed a novel targeting composite peptide BRBP1-TAT-KLA comprising of three elements: a brain metastatic breast carcinoma cell (231-BR)-binding peptide BRBP1, a cell penetrating peptide TAT, and a proapoptotic peptide KLA. This composite peptide efficiently internalized in 231-BR cells and consequently… CONTINUE READING
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