Corpus ID: 13721789

Enhanced antitumor activity of ursolic acid combined with cerulenin in osteosarcoma

  title={Enhanced antitumor activity of ursolic acid combined with cerulenin in osteosarcoma},
  author={Suchi Qiao and Cheng Li and C. Liu and D. Zhu and Wubuli Azhati and Z. Wang},
  • Suchi Qiao, Cheng Li, +3 authors Z. Wang
  • Published 2016
  • The present study was devised to investigate the effect of ursolic acid and cerulenin combination on osteosarcoma with an aim to develop an effective treatment strategy. Inhibition of cell growth was observed by MTT assay while as SENP5 expression by quantitative PCR and western blotting analysis in U2OS osteosarcoma cell line and HOB cells. The percentage of apoptotic cells and cell cycle distribution was determined using EPICS XL flow cytometer and System II software. For TUNEL assays to… CONTINUE READING

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