Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.

@article{Hostetler2006EnhancedAE,
  title={Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.},
  author={Karl Y. Hostetler and Steffney Rought and Kathy A. Aldern and Julissa Trahan and James R. Beadle and Jacques Corbeil},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 1},
  pages={156-9}
}
Nearly all cervical cancers are associated with the high-risk subtypes of human papillomavirus (HPV) expressing the E6 and E7 oncoproteins. The E6 and E7 oncoproteins reduce cellular levels of the p53 and the retinoblastoma (pRb) tumor suppressors, respectively, and represent an important component of the malignant phenotype. Several groups have shown that treatment with cidofovir suppresses levels of E6 and E7, restoring cellular p53 and pRb levels, in turn slowing cell replication and… CONTINUE READING
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