Enhanced antibody response to liposome-associated protein antigens: preferential stimulation of IgG2a/b production.

@article{Phillips1992EnhancedAR,
  title={Enhanced antibody response to liposome-associated protein antigens: preferential stimulation of IgG2a/b production.},
  author={N. C. Phillips and Andrew Emili},
  journal={Vaccine},
  year={1992},
  volume={10 3},
  pages={
          151-8
        }
}
The effect of liposome encapsulation on the antibody response to bovine serum albumin (BSA), human carcinoembryonic antigen (CEA) and sheep IgG (sIgG) has been determined in the mouse. Dipalmitoylphosphatidylcholine/dimyristolylphosphatidylglycerol liposomes (10:1 molar ratio; 1 mumol) containing BSA, CEA or sIgG induced significant levels of IgG antibodies after one injection, and enhanced the proportion of IgG2a/2b to IgG1 on subsequent boost injection. The IgG antibody titre induced by… CONTINUE READING

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