Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer

@inproceedings{Lee2016EnhancedAA,
  title={Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer},
  author={Kyung-Min Lee and Minju Lee and Jiwoo Lee and Sung Wuk Kim and Hyeong-Gon Moon and Dong Young Noh and Wonshik Han},
  booktitle={Oncotarget},
  year={2016}
}
Metformin, which is a drug commonly used to treat type 2 diabetes, has shown anti-tumor effects in numerous experimental, epidemiologic, observational, and clinical studies. Here, we report a new metformin derivative, metformin-butyrate (MFB). Compared to metformin-HCl, it more potently activates AMPK, inhibits mTOR, and impairs cell cycle progression at S… CONTINUE READING