Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model.

@article{Kwon2009EnhancedAM,
  title={Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model.},
  author={J. Kwon and I. Park and A. Cho and S. Shin and M. Hong and S. Y. Jeong and Yong Sook Kim and J. Min and M. Jeong and W. J. Kim and S. Jo and S. Pun and J. Cho and Jong Chun Park and J. Kang and Y. Ahn},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2009},
  volume={138 2},
  pages={
          168-76
        }
}
  • J. Kwon, I. Park, +13 authors Y. Ahn
  • Published 2009
  • Biology, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
Thermo-responsive hydrogel-mediated gene transfer may be preferred for the muscle, because the release of DNA into the surrounding tissue can be controlled by the 3-dimensional structure of the hydrogel. Such a system for the controlled release of a therapeutic gene may extend the duration of gene expression. Here, a thermo-responsive, biodegradable polymeric hydrogel was synthesized for local gene transfer in the heart. Initially, the luciferase gene was delivered into mouse heart. The… Expand
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  • Journal of controlled release : official journal of the Controlled Release Society
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