Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector.

@article{Sato1998EnhancedAS,
  title={Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector.},
  author={Yoshiki Sato and Kiyoshi Tanaka and Gwang Ju Lee and Yumi Kanegae and Yasuyoshi Sakai and Shuichi Kaneko and Hidekazu Nakabayashi and T. Tamaoki and Izumu Saito},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={244 2},
  pages={455-62}
}
A tissue-specific promoter is potentially valuable for the study of specific gene function and for gene therapy, as it permits a linked cytotoxic or any other gene to be expressed specifically in target cells. The expression levels of such promoters are generally low, and we have therefore developed a novel and general method to enhance the expression level of a tissue-specific promoter while maintaining specificity. We constructed a "regulator" recombinant adenovirus (rAd) producing the site… CONTINUE READING

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