Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis.

@article{Melchiorri1998EnhancedAC,
  title={Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis.},
  author={Chiara Melchiorri and Riccardo Melic{\`o}ni and Luigi Frizziero and Tania Silvestri and Lia Pulsatelli and Ilaria Mazzetti and Rosa Maria Borz{\`i} and Mariagrazia Uguccioni and Andrea Facchini},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 12},
  pages={
          2165-74
        }
}
OBJECTIVE To evaluate the sites of expression of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and inducible nitric oxide synthase (iNOS) in patients with inflammatory and degenerative joint diseases. METHODS Cytokines and iNOS were detected by immunohistochemistry analysis of synovial and cartilage biopsy specimens obtained at knee arthroscopy in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), osteoarthritis (OA), and traumatic knee arthritis… CONTINUE READING
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