Enhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis.

Abstract

Genetic variants of transthyretin (TTR) cause systemic amyloidosis and wild-type TTR may also in some situations produce amyloid fibrils. We have analyzed wild-type and variant TTRs by mass spectrometry and found that TTR preparations from all individuals demonstrated free TTR, TTR conjugated with thiol compounds and several minor components. We previously… (More)

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@article{Kishikawa1999EnhancedAO, title={Enhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis.}, author={Masao Kishikawa and T. Nakanishi and A. Miyazaki and Ai Shimizu}, journal={Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis}, year={1999}, volume={6 3}, pages={183-6} }