Enhanced alcohol-seeking behavior by nicotine in the posterior ventral tegmental area of female alcohol-preferring (P) rats: modulation by serotonin-3 and nicotinic cholinergic receptors

@article{Hauser2014EnhancedAB,
  title={Enhanced alcohol-seeking behavior by nicotine in the posterior ventral tegmental area of female alcohol-preferring (P) rats: modulation by serotonin-3 and nicotinic cholinergic receptors},
  author={Sheketha R. Hauser and Gerald A Deehan and Jamie E. Toalston and Richard L. Bell and William J. Mcbride and Zachary A. Rodd},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={3745-3755}
}
RationaleAlcohol and nicotine co-use can reciprocally promote self-administration and drug-craving/drug-seeking behaviors. To date, the neurocircuitry in which nicotine influences ethanol (EtOH) seeking has not been elucidated. Clinical and preclinical research has suggested that the activation of the mesolimbic dopamine system is involved in the promotion of drug seeking. Alcohol, nicotine, and serotonin-3 (5-HT3) receptors interact within the posterior ventral tegmental area (pVTA) to… 
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BACKGROUND Nicotine and alcohol co-abuse is highly prevalent. Recently, we have shown that nicotine infusion in the basal forebrain (BF) increases alcohol consumption. As nucleus accumbens (NAc) is
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The antero-posterior heterogeneity of the ventral tegmental area
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TLDR
The results suggest that the p-VTA is a neuroanatomical substrate mediating alcohol-seeking behavior and that activation of local DA neurons is involved.
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TLDR
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TLDR
The results of this study demonstrate that acute effects of nicotine on EtOH-seeking and relapse behaviors may be time dependent, with the immediate effects being a result of nicotine possibly acting as a substitute for EtOH, whereas with a delay of 4 hours, priming effects of Nicotine alterations in nicotinic receptors, and/or the effects of cotinine and nornicotine may enhance the expression of Et OH-seekingand relapse behaviors.
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