Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

@article{Saudou1994EnhancedAB,
  title={Enhanced aggressive behavior in mice lacking 5-HT1B receptor.},
  author={Fr{\'e}d{\'e}ric Saudou and Djamel Ait Amara and Andr{\'e}e Di{\'e}rich and Marianne Lemeur and Sylvie Ramboz and Louis S{\'e}gu and Marie Christine Buhot and Ren{\'e} Hen},
  journal={Science},
  year={1994},
  volume={265 5180},
  pages={
          1875-8
        }
}
The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect… CONTINUE READING
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5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze.

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