Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection.

@article{Schmitt2013EnhancedaffinityMT,
  title={Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection.},
  author={Thomas M Schmitt and David H. Aggen and Ingunn M. Stromnes and Michelle L Dossett and Sarah A. Richman and David M. Kranz and Philip D. Greenberg},
  journal={Blood},
  year={2013},
  volume={122 3},
  pages={348-56}
}
Many of the most promising tumor antigens for T-cell-based cancer immunotherapies are unmodified self-antigens. Unfortunately, the avidity of T cells specific for these antigens is limited by central tolerance during T-cell development in the thymus, resulting in decreased anti-tumor efficacy of these T cells. One approach to overcoming this obstacle is to mutate T-cell receptor (TCR) genes from naturally occurring T cells to enhance the affinity for the target antigen. These enhanced-affinity… CONTINUE READING
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