Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients.

@article{Lee2012EnhancedAB,
  title={Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients.},
  author={Hsing-Feng Lee and Jen-Chuen Hsieh and Ching-Liang Lu and Tzu-Chen Yeh and Cheng-Hao Tu and Chou-Ming Cheng and David M. Niddam and Han-Chieh Lin and Fa-Yauh Lee and F B Chang},
  journal={Pain},
  year={2012},
  volume={153 6},
  pages={1301-10}
}
Placebo analgesia is a psychosocial context effect that is rarely studied in visceral pain. Patients with irritable bowel syndrome (IBS) exhibit visceral hyperalgesia and heightened affective/cognitive brain region activation during visceral stimuli. Psychological factors alter the pain and brain activation pattern, and these changes are more pronounced in IBS patients. Expectation constitutes the major neuropsychological mechanism in the placebo effect. This study confirmed the heightened… CONTINUE READING
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