Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.

@article{Rebola2003EnhancedAA,
  title={Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.},
  author={Nelson Rebola and Ana M. Sebasti{\~a}o and Alexandre de Mendonça and Catarina Resende de Oliveira and Joaquim Alexandre Ribeiro and Rodrigo A Cunha},
  journal={Journal of neurophysiology},
  year={2003},
  volume={90 2},
  pages={1295-303}
}
Adenosine either inhibits or facilitates synaptic transmission through A1 or A2A receptors, respectively. Since A2A receptor density increases in the limbic cortex of aged (24 mo) compared with young adult rats (2 mo), we tested if A2A receptor modulation of synaptic transmission was also increased in aged rats. The A2A receptor agonist, CGS21680 (10 nM), caused a larger facilitation of the field excitatory postsynaptic potential (fEPSP) slope in hippocampal slices of aged (38%) than in young… CONTINUE READING

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