Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.

@article{Wang2010EnhancedAI,
  title={Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.},
  author={Dingyan Wang and Alexander Stewart and Lihua Zhuang and Yuanxiao Zhu and Youdong Wang and Changxin Shi and Armand Keating and Arthur S Slutsky and Haibo Zhang and Xiao-Yan Wen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 3},
  pages={
          947-56
        }
}
Hacs1, a SH3 and SAM domain-containing adaptor protein, is up-regulated by IL-4 in activated B cells and strongly expressed in dendritic cells. To elucidate the function of Hacs1 in immune regulation, we generated Hacs1(-/-) mice by deletion of the SH3 and SAM domains. Hacs1(-/-) mice were viable and fertile and had normal bone marrow B-cell development and normal splenic T- and B-cell populations. However, adult Hacs1(-/-) mice had increased peritoneal B1a cells (IgM(+)CD5(+)). On immunization… CONTINUE READING
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