Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.


BACKGROUND We recently demonstrated that phospholipase C (PLC)-delta1 activity in cultured skin fibroblasts obtained from patients with coronary spastic angina (CSA) is enhanced. We tested the hypothesis that structural abnormality in PLC-delta1 isoform is a cause of the enhanced activity. METHODS AND RESULTS Sequence analysis of the cDNA coding for PLC… (More)


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