Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide-lipid complexes.

Abstract

We demonstrate that recent observed increases in cell permeation activity of cyclic peptides via transporter sequences is due to the underlying phase behavior of peptide-lipid complexes and its relation to the topological requirement of membrane permeation. We also show how these effects can be amplified by incorporating hydrophobicity in these sequences. 

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Cite this paper

@article{Zhao2012EnhancedAO, title={Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide-lipid complexes.}, author={Kun Zhao and Uh-Joo Choe and Daniel T. Kamei and Gerard C. L. Wong}, journal={Soft matter}, year={2012}, volume={8 24}, pages={6430-6433} }