Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation.

@article{Lapteva2007EnhancedAO,
  title={Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation.},
  author={Natalia Lapteva and Mamatha R. Seethammagari and Brent A Hanks and Jianghong Jiang and Jonathan M. Levitt and Kevin M. Slawin and David M. Spencer},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={
          10528-37
        }
}
Despite the potency of dendritic cells (DC) as antigen-presenting cells for priming adaptive immunity, DC-based cancer vaccines have been largely insufficient to effectively reduce tumor burden or prevent tumor progression in most patients. To enhance DC-based vaccines, we used the combination of a synthetic ligand-inducible CD40 receptor (iCD40) along with Toll-like receptor-4 (TLR-4) ligation in human monocyte-derived DCs. The iCD40 receptor permits targeted, reversible activation of CD40 in… CONTINUE READING

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