Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis

@article{Lithanatudom2010EnhancedAO,
  title={Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis},
  author={Pathrapol Lithanatudom and Tirawat Wannatung and Amporn Leecharoenkiat and Saovaros Svasti and Suthat Fucharoen and Duncan R Smith},
  journal={Annals of Hematology},
  year={2010},
  volume={90},
  pages={747-758}
}
Erythropoiesis in β-thalassemia patients is ineffective, primarily because of death of the erythroid progenitor cells at the polychromatic normoblast stage. While it is known that autophagy plays a critical role during erythropoiesis by removing organelles from erythroid cells during terminal differentiation, its role in erythroid cells whose function is impaired remains to be explored. To investigate this, CD34+ erythroid progenitor cells from normal controls and β-thalassemia/Hb E patients… CONTINUE READING