Enhanced activation of RhoA by angiotensin II in SHR preglomerular microvascular smooth muscle cells.

@article{Jackson2005EnhancedAO,
  title={Enhanced activation of RhoA by angiotensin II in SHR preglomerular microvascular smooth muscle cells.},
  author={Edwin K Jackson and Bradley T. Andresen and Tammy M. Seasholtz and Chongxue Zhu and Guillermo G. Romero},
  journal={Journal of cardiovascular pharmacology},
  year={2005},
  volume={45 4},
  pages={283-5}
}
Angiotensin II causes a greater renal vasoconstriction in spontaneously hypertensive rats (SHR) than in normotensive Wistar Kyoto rats (WKY), and alpha2-adrenoceptor agonists potentiate angiotensin II-induced renal vasoconstriction more in SHR. Because angiotensin II activates RhoA, and RhoA contributes to vasoconstriction, we tested the hypothesis that the ability of angiotensin II to stimulate RhoA in preglomerular vascular smooth muscle cells and the ability of alpha2-adrenoceptor activation… CONTINUE READING