Enhanced Th2 immunity after DNA prime–protein boost immunization with amyloid β (1–42) plus CpG oligodeoxynucleotides in aged rats

@article{Subramanian2008EnhancedTI,
  title={Enhanced Th2 immunity after DNA prime–protein boost immunization with amyloid β (1–42) plus CpG oligodeoxynucleotides in aged rats},
  author={Sthanusubramania Sankara Subramanian and A N Divya Shree},
  journal={Neuroscience Letters},
  year={2008},
  volume={436},
  pages={219-222}
}
Generation and accumulation of fibrillar amyloid beta (Abeta) is widely considered as the pathogenic basis of neurodegeneration in Alzheimer's disease (AD). Both active immunization with fibrillar Abeta and passive immunization with anti-Abeta antibodies in transgenic mouse models of AD result in prevention/dissociation of Abeta plaque formation and restoration of cognitive functions. However, similar immunization studies in humans had to be halted because 6% of the AD patients developed acute… CONTINUE READING
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