Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

  title={Enhanced T cell responses due to diacylglycerol kinase ζ deficiency},
  author={Xiao-Ping Zhong and Ehmonie A. Hainey and Benjamin A. Olenchock and Martha S Jordan and Jonathan Scott Maltzman and Kim E Nichols and Hao Shen and Gary A Koretzky},
  journal={Nature Immunology},
Much is known about how T cell receptor (TCR) engagement leads to T cell activation; however, the mechanisms terminating TCR signaling remain less clear. Diacylglycerol, generated after TCR ligation, is essential in T cells. Its function must be controlled tightly to maintain normal T cell homeostasis. Previous studies have shown that diacylglycerol kinase ζ (DGKζ), which converts diacylglycerol to phosphatidic acid, can inhibit TCR signaling. Here we show that DGKζ-deficient T cells are… CONTINUE READING


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Diacylglycerol kinase - θ is localized in the speckle domains of the nucleus

G. Tabellini
Exp . Cell Res . • 2003

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