Enhanced T cell apoptosis in common variable immunodeficiency: negative role of the fas/fasligand system and of the Bcl-2 family proteins and possible role of TNF-RS.

@article{Renzo2001EnhancedTC,
  title={Enhanced T cell apoptosis in common variable immunodeficiency: negative role of the fas/fasligand system and of the Bcl-2 family proteins and possible role of TNF-RS.},
  author={Michela Di Renzo and Diego Serrano and Zongxiang Zhou and Italas George and Kevin Becker and Charlotte Cunningham-Rundles},
  journal={Clinical and experimental immunology},
  year={2001},
  volume={125 1},
  pages={117-22}
}
CVI is a primary immunodeficiency characterized by a failure of B cell differentiation associated with an array of T cell defects, such as enhanced T cell apoptosis. In this study we investigated the mechanisms underlying CVI enhanced T cell death. We analysed both the expression of Fas using flow cytometry techniques and the expression of FasL mRNA using… CONTINUE READING