Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation

@article{Saxena2013EnhancedSG,
  title={Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation},
  author={N. Saxena and S. Muthukumaraswamy and A. Diukova and Krish D. Singh and Judith E. Hall and R. Wise},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABAA agonist and sedative… Expand
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References

SHOWING 1-10 OF 74 REFERENCES
Spectral properties of induced and evoked gamma oscillations in human early visual cortex to moving and stationary stimuli.
TLDR
It is suggested that early visual areas encode moving and stationary percepts via activity at higher and lower gamma frequencies, respectively. Expand
Short- and Long-Term Effects of Cholinergic Modulation on Gamma Oscillations and Response Synchronization in the Visual Cortex
TLDR
Cholinergic modulation plays a crucial role both in the fast, state-dependent facilitation of gamma oscillations and response synchronization and in use-dependent long-term modifications of cortical dynamics that favor synchronization of responses in the gamma-frequency range. Expand
Antagonistic relationship between gamma power and visual evoked potentials revealed in human visual cortex.
TLDR
The results show a consistent antagonism between subdural ERP and gamma power although both are considered markers for neural activity and hypothesize that the ERP suppression is due to a desynchronization of neuronal firing resulting from recurrent neural activity in the vicinity of the freshly stimulated neurons and not an attenuation of the overall neural activity. Expand
Cholinergic Enhancement of Visual Attention and Neural Oscillations in the Human Brain
TLDR
These findings show that cholinergic neuromodulation enhances attentional selection via an impact on oscillatory synchrony in visual cortex, for low rather than high frequencies, in relation to proposals that lower-frequency oscillations are generated by feedback pathways within visual cortex. Expand
Transient Induced Gamma-Band Response in EEG as a Manifestation of Miniature Saccades
The induced gamma-band EEG response (iGBR) recorded on the scalp is widely assumed to reflect synchronous neural oscillation associated with object representation, attention, memory, andExpand
Stimuli of varying spatial scale induce gamma activity with distinct temporal characteristics in human visual cortex
TLDR
It is suggested that stimulus specific frequency characteristics of MEG signals can be mapped to processes of neuronal synchronization within the framework of coupled dynamical systems. Expand
Human gamma-frequency oscillations associated with attention and memory
TLDR
Recent findings demonstrating human gamma-frequency activity associated with attention and memory in both sensory and non-sensory areas are discussed. Expand
Long-term enhanced desynchronization of the alpha rhythm following tetanic stimulation of human visual cortex
TLDR
Because ERD of the alpha rhythm is thought to represent active cortex, these results suggest that the visual tetanus induces long-lasting cortical changes, with stronger neuronal assemblies and increased neuronal output. Expand
Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans
TLDR
The results are supportive of recent theories suggesting that these functional neuroimaging metrics are dependent on the excitation/inhibition balance in an individual's cortex and have important implications for the interpretation of functional imaging results, particularly when making between-group comparisons in clinical research. Expand
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
TLDR
The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation. Expand
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