Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

@article{Ernst2009EnhancedSA,
  title={Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.},
  author={Marianne B Ernst and Claudia Maria Wunderlich and Simon Hess and Moritz Paehler and Andrea Mesaros and Sergei B. Koralov and Andr{\'e} Kleinridders and Andreas Husch and Heike M{\"u}nzberg and Brigitte Hampel and Jens Alber and Peter Kloppenburg and Jens C. Br{\"u}ning and F Thomas Wunderlich},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 37},
  pages={11582-93}
}
Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothalamus plays an important role in maintenance of energy homeostasis. While Stat3 activation in POMC neurons is required for POMC expression, the role of elevated basal Stat3 activation as present in the development of obesity has not been directly addressed. Here, we have generated and characterized mice expressing a constitutively active version of Stat3 (Stat3-C) in POMC neurons (Stat3-C(POMC… CONTINUE READING