Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells

Abstract

Platelet-derived growth factor (PDGF) plays an essential role in proliferation of vascular smooth muscle cells (VSMCs). The Rb/E2F and TSC/mTOR pathways contribute to the proliferation of VSMCs, but its exact roles in PDGF-induced proliferation are unclear. In this study, we demonstrated the roles of Rb/E2F and TSC/mTOR pathways in PDGF-induced… (More)
DOI: 10.1371/journal.pone.0170036

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Cite this paper

@inproceedings{Li2017EnhancedRA, title={Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells}, author={Yue Li and Xuan Li and Jie Liu and Wei Dong Guo and Hongchao Zhang and Jianchang Wang}, booktitle={PloS one}, year={2017} }