Enhanced ROS production by NADPH oxidase is correlated to changes in antioxidant enzyme activity in human heart failure.

@article{Borchi2010EnhancedRP,
  title={Enhanced ROS production by NADPH oxidase is correlated to changes in antioxidant enzyme activity in human heart failure.},
  author={Elisabetta Borchi and Valentina Bargelli and Francesca Stillitano and Carla Giordano and Mariangela Sebastiani and Paolo Antonio Nassi and Giulia d'Amati and Elisabetta Cerbai and Chiara Nediani},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1802 3},
  pages={
          331-8
        }
}
In pathological conditions, the balance between reactive oxygen species (ROS) and antioxidants may shift toward a relative increase of ROS, resulting in oxidative stress. Conflicting data are available on antioxidant defenses in human failing heart and they are limited to the left ventricle. Thus, we aimed to investigate and compare the source of oxidant and antioxidant enzyme activities in the right (RV) and left (LV) ventricles of human failing hearts. We found a significant increase in… CONTINUE READING
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