Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.

@article{Robinson2017EnhancedPT,
  title={Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.},
  author={M. Robinson and S. Dasari and A. Konopka and Matthew L. Johnson and S. Manjunatha and Raul Ruiz Esponda and R. Carter and I. Lanza and K. Nair},
  journal={Cell metabolism},
  year={2017},
  volume={25 3},
  pages={
          581-592
        }
}
The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic capacity and skeletal muscle mitochondrial respiration. HIIT revealed a more robust increase in gene transcripts than other exercise modalities, particularly in older adults… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to evaluate the changes of muscle, in microgravity. Which will help explain the health benefits of exercise. There are tests that can be done to tell… Expand
ConditionsSarcopenia
InterventionOther, Procedure
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The roles played by transient transcriptome responses to acute exercise and by changes in baseline gene expression during up-regulation of protein content in human skeletal muscle were investigated and it was found that proteins with different functions are regulated differently at the transcriptional level. Expand
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It is reported that training volume may be a critical factor affectingChanges in mitochondrial content, whereas relative exercise intensity is an important determinant of changes in mitochondrial respiratory function. Expand
Impact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function
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The evidence on the effects of resistance exercise on skeletal muscle mitochondrial biogenesis, content and function is addressed and fatiguing low-load resistance exercise regimens may possess the ability to stimulate muscle mitochondrial adaptations without compromising muscle myofibrillar accretion. Expand
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Adaptation to regular exercise is associated not only with a transient (over several hours) increase in expression of many contractile activity-specific genes, but also with a pronounced change (an increase or decrease) inexpression of a large number of genes under baseline conditions. Expand
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