Enhanced Pressor Response to Increased CSF Sodium Concentration and to Central Angiotensin I in Heterozygous α2 Na, K-ATPase Knockout Mice*


Intracerebroventricular (i.c.v.) infusion of NaCl mimics the effects of a high-salt diet in salt-sensitive hypertension, raising the sodium concentration in the cerebrospinal fluid (CSF [Na]) and subsequently increasing the concentration of an endogenous ouabain-like substance (OLS) in the brain. The OLS in turn inhibits the brain Na, K-ATPase, causing an… (More)


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