Enhanced Peptide Identification by Electron Transfer Dissociation Using an Improved Mascot Percolator*

@inproceedings{Wright2012EnhancedPI,
  title={Enhanced Peptide Identification by Electron Transfer Dissociation Using an Improved Mascot Percolator*},
  author={James C Wright and Mark O Collins and Lu Yu and Lukas K{\"a}ll and Markus Brosch and Jyoti S Choudhary},
  booktitle={Molecular & cellular proteomics : MCP},
  year={2012}
}
Peptide identification using tandem mass spectrometry is a core technology in proteomics. Latest generations of mass spectrometry instruments enable the use of electron transfer dissociation (ETD) to complement collision induced dissociation (CID) for peptide fragmentation. However, a critical limitation to the use of ETD has been optimal database search software. Percolator is a post-search algorithm, which uses semi-supervised machine learning to improve the rate of peptide spectrum… CONTINUE READING

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