Enhanced Pedigree Error Detection

@article{Sun2002EnhancedPE,
  title={Enhanced Pedigree Error Detection},
  author={L. Sun and K. Wilder and M. S. McPeek},
  journal={Human Heredity},
  year={2002},
  volume={54},
  pages={110 - 99}
}
  • L. Sun, K. Wilder, M. S. McPeek
  • Published 2002
  • Computer Science, Medicine
  • Human Heredity
  • Accurate information on the relationships among individuals in a study is critical for valid linkage analysis. We extend the MLLR, EIBD, AIBS and IBS tests for detection of misspecified relationships to a broader range of relative pairs, and we improve the two-stage screening procedure for analyzing large data sets. We have developed software, PREST, which calculates the test statistics and performs the corresponding hypothesis tests for relationship misclassification in general outbred… CONTINUE READING
    138 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Detecting Pedigree Relationship Errors.
    • L. Sun
    • Computer Science, Medicine
    • Methods in molecular biology
    • 2017
    • 9
    Improving Pedigree-based Linkage Analysis by Estimating Coancestry Among Families
    • 16
    • PDF
    Linkage analysis without defined pedigrees
    • 40
    Non-identifiable Pedigrees and a Bayesian Solution
    • 7
    • PDF
    Pedigree and genotype errors in the Framingham Heart Study
    • 7
    • Highly Influenced
    Accurate Phasing of Pedigree Genotypes Using Whole Genome Sequence Data
    • PDF

    References

    SHOWING 1-10 OF 21 REFERENCES
    Detection of Misspecified Relationships in Inbred and Outbred Pedigrees
    • 16
    • PDF
    Relationship inference from trios of individuals, in the presence of typing error.
    • 63
    • PDF
    Statistical tests for detection of misspecified relationships by use of genome-screen data.
    • 327
    A test statistic to detect errors in sib-pair relationships.
    • 61
    PedCheck: a program for identification of genotype incompatibilities in linkage analysis.
    • 2,152
    • PDF
    Identifying marker typing incompatibilities in linkage analysis.
    • 61
    Improved inference of relationship for pairs of individuals.
    • 276
    • PDF
    Estimation of pairwise relationships in the presence of genotyping errors.
    • 121
    Relationship Estimation in Affected Sib Pair Analysis of Late-Onset Diseases
    • H. Goering, J. Ott
    • Biology, Medicine
    • European journal of human genetics : EJHG
    • 1997
    • 105
    Accurate inference of relationships in sib-pair linkage studies.
    • 277
    • PDF