Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.

@article{Sadagopal2010EnhancedPE,
  title={Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.},
  author={Shanmugalakshmi Sadagopal and Shelly L. Lorey and Louise Barnett and Deborah Sutherland and Rebecca J Basham and Husamettin Erdem and Spyros A. Kalams and David W. Haas},
  journal={Journal of virology},
  year={2010},
  volume={84 1},
  pages={131-40}
}
During chronic viral infections, T cells are exhausted due to constant antigen exposure and are associated with enhanced programmed death 1 (PD-1) expression. Deficiencies in the PD-1/programmed death-ligand 1 (PD-L1) pathway are associated with autoimmune diseases, including those of the central nervous system (CNS). To understand the role of PD-1 expression in regulating T-cell immunity in the CNS during chronic infection, we characterized PD-1 expression in cerebrospinal fluid (CSF) and… CONTINUE READING
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