Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules

  title={Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules},
  author={S. Peltier and Jean-Michel Oger and F. Lagarce and W. Couet and J. Beno{\^i}t},
  journal={Pharmaceutical Research},
  • S. Peltier, Jean-Michel Oger, +2 authors J. Benoît
  • Published 2006
  • Chemistry, Medicine
  • Pharmaceutical Research
  • PurposeThe aim of this study was to evaluate the pharmacokinetics of paclitaxel-loaded lipid nanocapsules (LNC) in rats to assess the intrinsic effect of the dosage form on the improvement of paclitaxel oral exposure.MethodsPaclitaxel-loaded LNC were prepared and characterized in terms of size distribution, drug payload, and the kinetics of paclitaxel crystallization. Taxol®, Taxol® with verapamil, or paclitaxel-loaded LNC were administered orally to rats. The plasma concentration of paclitaxel… CONTINUE READING
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