Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules

@article{Peltier2006EnhancedOP,
  title={Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules},
  author={S. Peltier and Jean-Michel Oger and F. Lagarce and W. Couet and J. Beno{\^i}t},
  journal={Pharmaceutical Research},
  year={2006},
  volume={23},
  pages={1243-1250}
}
  • S. Peltier, Jean-Michel Oger, +2 authors J. Benoît
  • Published 2006
  • Chemistry, Medicine
  • Pharmaceutical Research
    • PurposeThe aim of this study was to evaluate the pharmacokinetics of paclitaxel-loaded lipid nanocapsules (LNC) in rats to assess the intrinsic effect of the dosage form on the improvement of paclitaxel oral exposure.MethodsPaclitaxel-loaded LNC were prepared and characterized in terms of size distribution, drug payload, and the kinetics of paclitaxel crystallization. Taxol®, Taxol® with verapamil, or paclitaxel-loaded LNC were administered orally to rats. The plasma concentration of paclitaxel… CONTINUE READING
    View on Springer
    ncbi.nlm.nih.gov
    220 Citations
    Highly Influencial Citations
    10
    Background Citations
    74
    Methods Citations
    8
    Results Citations
    7

    Figures, Tables, and Topics from this paper

    Figures and Tables

    Explore Further: Topics Discussed in This Paper

    220 Citations
    Citation Type

    Citation Type

    Development of Lipid-Based Nanoparticles for Enhancing the Oral Bioavailability of Paclitaxel
    • 62
    Pharmacokinetics and antitumor efficacy of paclitaxel-cyclodextrin complexes loaded in mucus-penetrating nanoparticles for oral administration.
    • 18
    • PDF
    In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor.
    • 20
    Biodistribution and in vivo performance of fattigation-platform theranostic nanoparticles.
    • 14
    Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study.
    • 91
    • PDF
    Enhanced oral bioavailability of paclitaxel formulated in vitamin E-TPGS emulsified nanoparticles of biodegradable polymers: in vitro and in vivo studies.
    • 85
    Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies
    • 44
    • PDF
    Improving Efficacy, Oral Bioavailability, and Delivery of Paclitaxel Using Protein-Grafted Solid Lipid Nanoparticles.
    • 47
    Niosomes encapsulating paclitaxel for oral bioavailability enhancement: preparation, characterization, pharmacokinetics and biodistribution
    • 24
    Mucoadhesive paclitaxel-loaded chitosan-poly (isobutyl cyanoacrylate) core-shell nanocapsules containing copaiba oil designed for oral drug delivery
    • 8

    References

    SHOWING 1-10 OF 43 REFERENCES
    Enhanced Oral Absorption of Paclitaxel in a Novel Self-Microemulsifying Drug Delivery System with or Without Concomitant Use of P-Glycoprotein Inhibitors
    • 147
    Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin.
    • J. Choi, Byung-Wok Jo, Y. Kim
    • Chemistry, Medicine
    • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
    • 2004
    • 125
    Formulating Paclitaxel in Nanoparticles Alters Its Disposition
    • 89
    A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.
    • L. Mu, S. Feng
    • Chemistry, Medicine
    • Journal of controlled release : official journal of the Controlled Release Society
    • 2003
    • 632
    • PDF
    Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers.
    • 102
    In Vitro and In Vivo Evaluation of Oral Heparin–Loaded Polymeric Nanoparticles in Rabbits
    • 189
    • PDF
    Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.
    • 195
    • PDF
    Enhanced Oral Bioavailability of Paclitaxel by Coadministration of the P-Glycoprotein Inhibitor KR30031
    • 122
    • Highly Influential
    • PDF
    Oral Delivery of Taxanes
    • 143
    Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.
    • 126
    • PDF