Enhanced Oral Delivery of Bisphosphonate by Novel Absorption Enhancers: Improvement of Intestinal Absorption of Alendronate by N-Acyl Amino Acids and N-Acyl Taurates and Their Absorption-Enhancing Mechanisms.

  title={Enhanced Oral Delivery of Bisphosphonate by Novel Absorption Enhancers: Improvement of Intestinal Absorption of Alendronate by N-Acyl Amino Acids and N-Acyl Taurates and Their Absorption-Enhancing Mechanisms.},
  author={Yuka Nakaya and Mayu Takaya and Yuta Hinatsu and Tammam Alama and Kosuke Kusamori and Hidemasa Katsumi and Toshiyasu Sakane and Akira Yamamoto},
  journal={Journal of pharmaceutical sciences},
  volume={105 12},

Figures and Tables from this paper

Improvement of the Solubility and Intestinal Absorption of Curcumin by N-Acyl Taurates and Elucidation of the Absorption-Enhancing Mechanisms.

Co-administration of CUR with either LMT or CMT is a simple and effective method to enhance oral delivery of CURE through the absorption-enhancing mechanisms of NATs.

Enhanced Intestinal Absorption of Insulin by Capryol 90, a Novel Absorption Enhancer in Rats: Implications in Oral Insulin Delivery

It is suggested that Capryol 90 is an effective absorption enhancer for improving the intestinal absorption of insulin, without inducing serious damage to the intestinal epithelium.

Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats

The outcomes propose that SLG-30 might improve the enteric transport of poorly absorbed substances through both transcellular and paracellular routes.

Improvement of intestinal absorption of curcumin by cyclodextrins and the mechanisms underlying absorption enhancement.

Efficient Oral Delivery of Poorly Water-Soluble Drugs Using Carnitine/Organic Cation Transporter 2-Mediated Polymeric Micelles.

The current study provided an efficient strategy to facilitate the oral absorption of water-insoluble and poorly absorbed agents using intestinal transporter-mediated polymeric micelles.



Development of polyethylene glycol-conjugated alendronate, a novel nitrogen-containing bisphosphonate derivative: evaluation of absorption, safety, and effects after intrapulmonary administration in rats.

PEG-alendronate is developed as a new delivery system for bisphosphonates that improves their BA and safety and effectively inhibited decreases in the width of the growth plate to a level similar to that achieved by intrapulmonary administration of alendronates in rats.

A peptide prodrug approach for improving bisphosphonate oral absorption.

The results indicate that the oral absorption of bisphosphonates can be improved by peptidyl prodrugs via the hPEPT1; however, other transporters may also be involved.

Sodium EDTA enhances intestinal absorption of two bisphosphonates

EDTA can, in certain circumstances, increase the intestinal absorption of bisphosphonates, the mechanism might involve an increase in available bisph phosphate and a change in mucosal permeability.

Polyamidoamine dendrimers as novel potential absorption enhancers for improving the small intestinal absorption of poorly absorbable drugs in rats.

Effectiveness and Toxicity Screening of Various Absorption Enhancers in the Rat Small Intestine: Effects of Absorption Enhancers on the Intestinal Absorption of Phenol Red and the Release of Protein and Phospholipids from the Intestinal Membrane

Local toxicity in rats was examined by assessing protein and phospholipid release as biological markers and sodium glycocholate and sodium taurocholate effectiveness as enhancers of the absorption of drugs in the rat small intestine were ranked.

Pharmacokinetics of Alendronate

Alendronate treatment results in an early and dose-dependent inhibition of skeletal resorption, which can be followed clinically with biochemical markers, and which ultimately reaches a plateau and is slowly reversible upon discontinuation of the drug.